Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
[Molecular pathological diagnosis of soft tissue tumors].
[pleomorphic liposarcoma]
Among
soft
tissue
tumors
,
which
have
some
difficulties
in
diagnosis
and
treatment
,
it
is
known
that
distinctive
chromosomal
and
gene
abnormalities
such
as
chromosomal
translocations
and
fusion
genes
resulting
from
these
translocations
can
be
detected
.
We
have
focused
on
the
research
and
development
of
split
-signal
DNA
probes
for
FISH
analysis
,
which
can
establish
an
accurate
diagnosis
by
detecting
the
specific
fusion
genes
for
soft
tissue
tumors
.
Using
these
probes
as
well
as
commercially
available
probes
,
we
conduct
the
FISH
analysis
on
formalin-fixed
,
paraffin-embedded
histological
specimens
to
apply
these
methods
to
the
routine
pathological
diagnosis
.
In
this
article
,
we
introduce
(
1
)
principle
of
detecting
fusion
genes
by
RT-PCR
and
FISH
,
(
2
)
outlines
of
FISH
using
split
-signal
probes
,
and
(
3
)
results
of
FISH
analysis
in
Ewing
sarcoma
/
PNET
,
rhabdomyosarcoma
,
pleomorphic
liposarcoma
and
extraskeletal
myxoid
chondrosarcoma
.
Diseases
Validation
Diseases presenting
"routine pathological diagnosis"
symptom
pleomorphic liposarcoma
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