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PML down-regulation in soft tissue sarcomas.
[pleomorphic liposarcoma]
To
date
,
little
is
known
concerning
the
promyelocytic
leukemia
gene
(
PML
)
status
in
tumors
of
different
origin
,
and
its
expression
has
never
been
evaluated
in
soft
tissue
sarcoma
.
The
aim
of
the
present
study
is
focused
on
the
identification
of
differences
in
terms
of
PML
protein
expression
between
different
types
of
soft
tissue
sarcoma
and
the
corresponding
normal
surrounding
tissue
.
PML
protein
expression
has
been
assessed
by
immunohistochemistry
in
six
different
histologic
types
of
soft
tissue
sarcoma
(
synovial
sarcoma
,
myofibroblastic
sarcoma
,
angiosarcoma
,
liposarcoma
,
pleomorphic
sarcoma
,
and
leiomyosarcoma
)
and
in
the
corresponding
normal
surrounding
tissue
.
PML
resulted
significantly
down-regulated
in
synovial
sarcoma
and
in
myofibroblastic
sarcoma
specimens
.
Also
in
angiosarcoma
samples
a
significative
difference
in
PML
expression
in
comparison
with
normal
specimens
has
been
detected
.
Interestingly
PML
protein
detection
showed
a
different
pattern
of
expression
in
the
three
liposarcoma
histology
types
compared
with
corresponding
nontumoral
tissues
.
In
particular
PML
protein
resulted
significantly
down-regulated
in
myxoid
liposarcoma
and
in
dedifferentiated
liposarcoma
.
On
the
contrary
no
statistically
significant
difference
was
observed
in
pleomorphic
liposarcoma
compared
to
normal
tissue
specimens
.
Further
investigations
are
needed
to
confirm
these
data
and
to
assess
the
possible
value
of
PML
expression
as
a
prognostic
factor
in
these
extremely
aggressive
diseases
.