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Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data.
[pleomorphic liposarcoma]
To
describe
the
MRI
features
of
liposarcomas
of
the
extremities
and
correlate
them
with
data
from
the
histologic
subtypes
.
Retrospective
study
of
20
cases
of
liposarcoma
of
the
extremities
identified
on
MRI
,
surgically
removed
and
confirmed
at
pathology
.
On
MRI
examination
,
T
1
-
and
T
2
-
weighted
fat-suppressed
and
non-fat-suppressed
images
were
acquired
then
gadolinium-enhanced
fat-suppressed
T
1
-
weighted
images
were
obtained
in
at
least
two
orthogonal
planes
.
Sixteen
female
and
four
male
patients
aged
12
to
77
years
old
at
presentation
,
in
16
cases
,
with
a
slowly
enlarging
painless
mass
(
demonstrating
no
associated
local
or
general
inflammatory
components
)
,
located
in
the
lower
extremity
(
16
cases
)
and
predominantly
located
in
the
thigh
(
13
cases
)
.
Pathologic
examination
revealed
three
cases
of
well-differentiated
liposarcoma
,
12
cases
of
myxoid
liposarcoma
one
of
which
with
round
cells
,
three
cases
of
pleomorphic
liposarcoma
,
one
case
of
dedifferentiated
liposarcoma
and
one
case
of
mixed
-
type
liposarcoma
.
MR
images
mostly
showed
well-circumscribed
tumors
(
19
cases
)
.
Well-differentiated
liposarcomas
typically
demonstrated
a
very
specific
diagnostic
appearance
as
a
predominantly
adipose
mass
containing
nonlipomatous
components
seen
as
thick
septa
that
may
show
nodularity
.
Other
subtypes
of
liposarcoma
demonstrated
a
small
amount
of
adipose
tissue
thus
producing
a
marbled
textural
pattern
on
T
1
-
weighted
images
particularly
in
myxoid
liposarcomas
(
9
cases
)
,
or
even
nonlipomatous
elements
in
high
-grade
liposarcomas
(
in
round
cell
liposarcoma
and
in
two
out
of
three
pleomorphic
liposarcomas
)
.
The
myxoid
subtype
has
also
a
relatively
characteristic
appearance
as
a
low
signal
intensity
noted
on
T
1
-
weighted
images
and
a
marked
high
signal
intensity
on
T
2
.
The
dedifferentiated
liposarcoma
has
a
very
specific
radiologic
appearance
as
a
nonlipomatous
component
within
a
predominantly
adipose
mass
,
simulating
that
of
well-differentiated
liposarcomas
.
MRI
of
extremity
liposarcomas
is
a
highly
reliable
and
sensitive
method
to
characterize
liposarcomas
.
Besides
its
value
in
the
diagnosis
of
liposarcoma
and
locoregional
extension
control
,
it
allows
proper
identification
of
the
specific
histologic
subtypes
of
liposarcoma
.
Level
IV
.
Rétrospective
diagnostic
study
.
Diseases
Validation
Diseases presenting
"small amount"
symptom
classical phenylketonuria
dystrophic epidermolysis bullosa
junctional epidermolysis bullosa
pleomorphic liposarcoma
pyruvate dehydrogenase deficiency
scrub typhus
systemic capillary leak syndrome
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