Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor.

[pleomorphic liposarcoma]

There is limited documentation on cytologic features of liposarcomas , especially pleomorphic liposarcomas (PLPSs ), in view of their rarity .We present cytomorphologic features of an uncommon case of epithelioid variant of a PLPS appearing as a recurrent mass in a young adult man . Fine needle aspiration cytology smears displayed prominent arborizing vasculature with numerous lipoblasts with well-defined vacuolated cytoplasm , indenting the nuclei . In addition , mitoses were conspicuously noted . Biopsy from the scar recurrence and following wide excision showed a multinodular tumor with solid arrangement of tumor cells , separated by delicate vessels . Cells displayed well defined cytoplasmic borders , including several lipoblasts and focal areas of spindly sarcomatous differentiation . Typical and atypical mitoses were conspicuously seen and myxoid areas were absent . Immunohistochemistry showed diffuse positivity for vimentin and S-100 ; cytokeratin showed weak , focal cytoplasmic positivity . CD 34 highlighted the delicate vasculature on tissue sections . Diagnosis of an epithelioid variant of a PLPS was finally offered .This rare case describes cytomorphologic features of an epithelioid variant of a PLPS , including prominent arborizing vasculature , a pattern that has invariably been described in a myxoid liposarcoma . Additionally , presence of numerous lipoblasts and mitoses led to the diagnosis of this rare variant .

Diseases
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Diseases presenting "well-defined vacuolated cytoplasm" symptom

pleomorphic liposarcoma

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