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A random Abstract
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New frontiers in the treatment of liposarcoma, a therapeutically resistant malignant cohort.
[pleomorphic liposarcoma]
The
adipogenic
origin-derived
liposarcoma
(
LPS
)
family
is
the
most
common
soft
tissue
sarcoma
histological
subtype
.
This
group
is
composed
of
three
categories
as
per
the
2002
WHO
guidelines
:
(
1
)
well-differentiated
and
dedifferentiated
liposarcoma
(
WDLPS
/
DDLPS
)
;
(
2
)
myxoid
and
round
cell
liposarcoma
(
MLS
and
RCL
)
;
and
(
3
)
pleomorphic
liposarcoma
(
PLS
)
.
While
clustered
together
,
these
histological
subtypes
are
widely
diverse
in
their
clinical
,
pathological
,
and
molecular
characteristics
.
In
general
,
surgery
still
remains
the
mainstay
of
LPS
therapy
and
the
only
approach
offering
the
potential
of
cure
.
Effective
therapeutic
strategies
for
locally
advanced
and
metastatic
disease
are
currently
lacking
and
are
crucially
needed
.
With
the
current
gradually
increasing
knowledge
of
LPS
genetic-
and
epigenetic-associated
deregulations
,
the
ultimate
goal
is
to
develop
drugs
that
can
specifically
eliminate
LPS
cells
while
sparing
normal
tissues
.
This
tumor
-tailored
target-orientated
approach
will
hopefully
result
in
a
significant
improvement
in
the
outcome
of
patients
suffering
from
these
poor
prognosis
malignancies
.
