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Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma.
[pleomorphic liposarcoma]
We
report
a
case
of
epithelioid
variant
of
pleomorphic
liposarcoma
(
EPL
)
found
in
the
the
infrapatellar
fat
pad
of
Hoffa
of
a
31
-
year
old
male
.
Histologically
,
the
predominant
population
was
formed
by
epithelioid
cells
with
eosinophilic
or
clear
cytoplasm
admixed
with
rare
pleomorphic
lipoblasts
.
The
immunohistochemical
panel
was
not
helpful
in
the
diagnosis
.
FISH
analysis
using
the
locus-
specific
indicator
CHOP
(
12
q
13
)
dual
color
break
apart
was
applied
to
representative
formalin-fixed
,
paraffin-embedded
tissue
sections
.
The
result
of
FISH
indicated
a
rearranged
CHOP
(
DDIT
3
)
gene
and
confirmed
the
diagnosis
of
EPL
.
The
EPL
should
be
differentiated
from
a
metastatic
carcinoma
or
other
type
of
sarcoma
.
In
these
cases
a
clinicopathological
correlation
and
an
exhaustive
sampling
of
the
specimen
for
demonstration
of
lipogenic
areas
or
pleomorphic
lipoblasts
is
always
necessary
.
FISH
with
demonstration
of
CHOP
gene
rearrangement
is
useful
in
providing
specific
ancillary
information
for
the
difficult
differential
diagnosis
of
this
case
.
