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Prediction of lack of response to neoadjuvant chemotherapy in rare breast tumour histology with Tc-99m sestamibi scintimammography.
[pleomorphic liposarcoma]
The
authors
report
a
case
of
a
47
-
year
-old
female
with
a
malignant
lump
in
the
right
breast
and
ipsilateral
axillary
nodal
involvement
.
She
was
pathologically
misinterpreted
as
a
case
of
ductal
cell
carcinoma
with
papillary
component
on
fine
needle
aspiration
cytology
(
FNAC
)
pre-operatively
.
On
lines
of
the
FNAC
report
,
the
patient
underwent
scintimammography
(
SMM
)
for
prediction
of
treatment
response
based
on
washout
pattern
.
The
SMM
revealed
rapid
washout
of
radiotracer
predictive
of
poor
responder
.
Despite
unfavourable
result
seen
with
SMM
,
the
patient
received
4
cycles
of
neo-adjuvant
chemotherapy
(
NACT
)
.
However
,
there
was
no
clinical
response
after
chemotherapy
.
The
post-surgical
histopathology
revealed
the
actual
histology
to
be
pleomorphic
liposarcoma
.
This
case
highlights
that
SMM
has
the
ability
to
predict
non-responsiveness
of
unusual
tumour
histology
to
standard
NACT
.
Diseases
Validation
Diseases presenting
"liposarcoma"
symptom
dedifferentiated liposarcoma
erdheim-chester disease
focal myositis
gm1 gangliosidosis
liposarcoma
pleomorphic liposarcoma
well-differentiated liposarcoma
This symptom has already been validated
