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Diagnostic Value of MDM2 and DDIT3 Fluorescence In Situ Hybridization in Liposarcoma Classification: A Single-Institution Experience.
[pleomorphic liposarcoma]
The
amplification
of
murine
double
minutes
(
MDM
2
)
is
the
primary
feature
of
well-differentiated
liposarcomas
(
WDLPS
)
and
dedifferentiated
liposarcomas
(
DDLPS
)
,
while
DDIT
3
rearrangement
is
the
main
one
of
myxoid
liposarcomas
(
MLPS
)
.
Our
aim
was
to
evaluate
the
added
value
of
MDM
2
amplification
and
DDIT
3
rearrangement
in
making
a
diagnosis
and
classifying
lipogenic
tumors
.
Eighty
-
two
cases
of
liposarcoma
and
60
lipomas
diagnosed
between
1995
and
2010
were
analysed
for
MDM
2
amplification
and
DDIT
3
rearrangement
using
a
fluorescence
in
situ
hybridization
(
FISH
)
.
The
subtypes
of
liposarcoma
were
reclassified
according
to
the
molecular
results
,
whose
results
were
reviewed
with
an
analysis
of
the
relevant
histologic
and
immunohistochemical
findings
.
One
case
of
lipoma
(
1
.
67
%
)
was
reclassified
as
a
WDLPS
.
Of
the
liposarcomas
,
13
.
4
%
(
16
/
82
)
were
reclassified
after
the
molecular
testing
.
Five
cases
of
MLPS
were
reclassified
as
four
cases
of
DDLPS
and
one
case
of
myxoid
lipoma
.
Two
cases
of
WDLPS
were
reclassified
as
one
case
of
spindle
cell
lipoma
and
another
case
of
myxofibrosarcoma
.
Four
cases
of
DDLPS
were
reclassified
as
two
cases
of
leiomyosarcoma
,
one
case
of
angiomyolipoma
and
another
case
of
fibroinflammatory
lesion
.
Of
the
six
cases
of
pleomorphic
liposarcoma
,
five
were
reclassified
as
DDLPS
.
In
our
series
,
a
critical
revision
of
diagnosis
was
found
at
a
rate
of
3
.
5
%
(
5
/
142
)
after
a
review
of
the
lipomatous
lesions
.
The
uses
of
molecular
testing
by
MDM
2
and
DDIT
3
FISH
were
valuable
to
make
an
accurate
subtyping
of
liposarcomas
as
well
as
to
differentiate
WDLPS
from
benign
lipomatous
tumor
.
