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Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification.
[pleomorphic liposarcoma]
Liposarcomas
are
among
the
most
common
soft
tissue
sarcomas
in
adulthood
.
The
purpose
of
the
study
is
to
perform
a
histopathologic
typing
according
to
World
Health
Organization
(
WHO
)
classification
of
cases
diagnosed
with
liposarcoma
and
to
examine
the
difference
of
p
53
and
MDM
2
expressions
.
The
haematoxylin-eosin
stained
sections
of
48
subjects
enrolled
in
the
study
have
been
evaluated
on
the
basis
of
the
WHO
classification
for
liposarcoma
and
sections
stained
using
p
53
and
MDM
2
.
Chi
-
Square
test
was
applied
.
20
subjects
were
diagnosed
with
well-differentiated
liposarcoma
(
WLS
)
,
16
myxoid
liposarcoma
(
ML
)
,
7
pleomorphic
liposarcoma
(
PL
)
,
and
5
de
-differentiated
liposarcoma
(
DLS
)
.
The
number
of
cases
stained
positive
with
MDM
2
and
p
53
were
positive
correlated
in
all
subjects
(
P
=
0
.
02
)
.
p
53
and
MDM
2
positivity
increased
in
high
grade
tumors
(
P
=
0
.
01
)
.
p
53
and
MDM
2
immuno-reactivity
was
found
to
be
potentially
useful
in
liposarcoma
diagnosis
but
a
definitive
implication
would
be
rather
unhealthy
due
to
the
small
number
of
cases
in
our
study
.
Diseases
Validation
Diseases presenting
"to examine the difference of p53 and mdm2 expressions"
symptom
pleomorphic liposarcoma
well-differentiated liposarcoma
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