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Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma.
[pleomorphic liposarcoma]
We
describe
a
case
of
ovarian
carcinosarcoma
occurring
in
a
60
-
year
-old
female
.
The
neoplasm
was
excised
after
neoadjuvant
chemotherapy
and
contained
a
predominant
heterologous
pleomorphic
rhabdomyosarcomatous
component
in
which
there
were
numerous
multivacuolated
rhabdomyoblasts
that
strongly
mimicked
lipoblasts
.
The
clear
cell
variant
of
rhabdomyosarcoma
is
rarely
documented
,
but
this
case
shows
a
highly
unusual
finding
in
which
the
rhabdomyoblasts
show
the
prominent
multivacuolation
with
nuclear
indentation
characteristic
of
and
indistinguishable
from
pleomorphic
lipoblasts
.
This
appears
to
represent
a
posttreatment
phenomenon
.
As
this
finding
might
conceivably
occur
in
other
rhabdomyosarcomas
after
chemotherapy
,
we
highlight
the
potential
for
diagnostic
confusion
with
pleomorphic
liposarcoma
,
which
is
usually
diagnosed
by
morphology
so
that
immunohistochemistry
for
muscle
markers
might
not
be
performed
.
Diseases
Validation
Diseases presenting
"which is usually diagnosed by morphology so that immunohistochemistry for muscle markers might not be performed"
symptom
pleomorphic liposarcoma
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