Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma.

[pleomorphic liposarcoma]

We describe a case of ovarian carcinosarcoma occurring in a 60 -year -old female . The neoplasm was excised after neoadjuvant chemotherapy and contained a predominant heterologous pleomorphic rhabdomyosarcomatous component in which there were numerous multivacuolated rhabdomyoblasts that strongly mimicked lipoblasts . The clear cell variant of rhabdomyosarcoma is rarely documented , but this case shows a highly unusual finding in which the rhabdomyoblasts show the prominent multivacuolation with nuclear indentation characteristic of and indistinguishable from pleomorphic lipoblasts . This appears to represent a posttreatment phenomenon . As this finding might conceivably occur in other rhabdomyosarcomas after chemotherapy , we highlight the potential for diagnostic confusion with pleomorphic liposarcoma , which is usually diagnosed by morphology so that immunohistochemistry for muscle markers might not be performed .

Diseases
Validation

Diseases presenting "neoplasm" symptom

adrenal incidentaloma

alexander disease

aromatase deficiency

carcinoma of the gallbladder

cholangiocarcinoma

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dentin dysplasia

erdheim-chester disease

esophageal adenocarcinoma

esophageal carcinoma

familial hypocalciuric hypercalcemia

focal myositis

hodgkin lymphoma, classical

hydrocephalus with stenosis of the aqueduct of sylvius

junctional epidermolysis bullosa

kabuki syndrome

liposarcoma

lymphangioleiomyomatosis

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wolf-hirschhorn syndrome

This symptom has already been validated