Unrestricted fruits and vegetables in the PKU diet: a 1-year follow-up.

[phenylketonuria]

Phenylketonuria (PKU ) therapy demands phenylalanine (Phe ) calculation . In most countries , almost all food is taken into account , even fruits and vegetables . We investigated whether unrestricted consumption of fruits and vegetables negatively influences metabolic control . Nineteen PKU children (2 -10 years ) started with 2 weeks of free or restricted fruit and vegetable intake . After 2 weeks , the regime changed from free to restricted or restricted to free (cross-over design ). Over the first 4 weeks , dried blood Phe concentration was measured , fruit and vegetable consumption recorded and nutrient intake calculated from diet records . Thereafter the diet was changed to free use of fruits and vegetables for all patients . Six and 12 months later , diet and Phe concentrations were monitored . Median Phe intake increased significantly by 65 mg /day (week 4 , P <0 .001 ), 68 mg /day (month 6 , P <0 .001 ) and 70 mg /day (month 12 , P <0 .001 ). Dried blood Phe concentrations remained stable (P =0 .894 ), as did the frequency of Phe concentrations above the recommended range (P =0 .592 ). In conclusion , PKU diet liberalization for fruits and vegetables seems unproblematic .

Diseases
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Diseases presenting "vegetables" symptom

phenylketonuria

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