Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The cyanobacterial bicarbonate transporter BicA: its physiological role and the implications of structural similarities with human SLC26 transporters.
[pendred syndrome]
The
cyanobacterial
Na
+
-
dependent
HCO
3
-
transporter
BicA
is
a
member
of
the
ubiquitous
and
important
SulP
/
SLC
26
family
of
anion
transporters
found
in
eukaryotes
and
prokaryotes
.
BicA
is
an
important
component
of
the
cyanobacterial
CO
2
concentrating
mechanism
,
an
adaptation
that
contributes
to
cyanobacteria
being
able
to
achieve
an
estimated
25
%
of
global
primary
productivity
,
largely
in
the
oceans
.
The
human
SLC
26
members
are
involved
in
a
range
of
key
cellular
functions
involving
a
diverse
range
of
anion
transport
activities
including
Cl-
/
HCO
3
-
,
I
-
/
HCO
3
-
,
and
SO
42
-
/
HCO
3
-
exchange
;
mutations
in
SLC
26
members
are
known
to
be
associated
with
debilitating
diseases
such
as
Pendred
syndrome
,
chondrodysplasias
,
and
congenital
chloride
diarrhoea
.
We
have
recently
experimentally
determined
the
membrane
topology
of
BicA
using
the
phoA-lacZ
reporter
system
and
here
consider
some
of
the
extrapolated
implications
for
topology
of
the
human
SLC
26
family
and
the
Sultr
plant
sulphate
transporters
.
Diseases
Validation
Diseases presenting
"extrapolated implications for topology of the human slc26 family"
symptom
pendred syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom