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The cyanobacterial bicarbonate transporter BicA: its physiological role and the implications of structural similarities with human SLC26 transporters.
[pendred syndrome]
The
cyanobacterial
Na
+
-
dependent
HCO
3
-
transporter
BicA
is
a
member
of
the
ubiquitous
and
important
SulP
/
SLC
26
family
of
anion
transporters
found
in
eukaryotes
and
prokaryotes
.
BicA
is
an
important
component
of
the
cyanobacterial
CO
2
concentrating
mechanism
,
an
adaptation
that
contributes
to
cyanobacteria
being
able
to
achieve
an
estimated
25
%
of
global
primary
productivity
,
largely
in
the
oceans
.
The
human
SLC
26
members
are
involved
in
a
range
of
key
cellular
functions
involving
a
diverse
range
of
anion
transport
activities
including
Cl-
/
HCO
3
-
,
I
-
/
HCO
3
-
,
and
SO
42
-
/
HCO
3
-
exchange
;
mutations
in
SLC
26
members
are
known
to
be
associated
with
debilitating
diseases
such
as
Pendred
syndrome
,
chondrodysplasias
,
and
congenital
chloride
diarrhoea
.
We
have
recently
experimentally
determined
the
membrane
topology
of
BicA
using
the
phoA-lacZ
reporter
system
and
here
consider
some
of
the
extrapolated
implications
for
topology
of
the
human
SLC
26
family
and
the
Sultr
plant
sulphate
transporters
.
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