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Immunohistochemical analysis of syndecan-1 in leukoplakia and oral submucous fibrosis.
[oral submucous fibrosis]
Syndecan-
1
is
abundant
in
normal
tissues
and
reduced
in
squamous
cell
carcinomas
.
Leukoplakia
and
oral
submucous
fibrosis
(
OSF
)
are
oral
pre-cancerous
disorders
that
have
potential
for
malignant
transformation
.
The
aim
of
this
study
was
to
evaluate
the
expression
of
syndecan-
1
in
leukoplakia
and
OSF
and
to
identify
its
role
as
a
reliable
marker
for
predicting
malignant
changes
.
Expression
of
syndecan-
1
was
examined
immunohistochemically
in
42
cases
of
oral
leukoplakia
with
or
without
epithelial
dysplasia
,
28
cases
of
OSF
and
10
cases
of
normal
oral
epithelia
as
control
.
Mann-
Whiteny
'
U
'
test
was
used
for
statistical
analysis
and
the
level
of
significance
was
fixed
at
P
<
0
.
05
.
Intense
syndecan-
1
expression
was
observed
in
nine
cases
with
normal
epithelium
.
Immunopositivity
was
lost
gradually
as
the
extent
of
epithelial
dysplasia
increased
.
The
significant
reduction
in
syndecan-
1
expression
was
observed
in
leukoplakia
as
epithelial
dysplasia
progressed
from
moderate
or
severe
.
Similarly
,
significant
reduction
was
observed
in
staining
intensities
in
OSF
with
dysplasia
.
The
results
reveal
that
down-regulation
of
syndecan-
1
expression
is
associated
with
dysplastic
changes
in
leukoplakia
and
OSF
.
Thus
syndecan-
1
can
be
considered
as
marker
for
predicting
malignant
changes
.