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Efficacy of spirulina as an antioxidant adjuvant to corticosteroid injection in management of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSF
)
is
a
chronic
condition
of
the
oral
cavity
which
results
in
permanent
disability
.
A
number
of
studies
have
proven
that
the
management
of
premalignant
diseases
should
include
antioxidants
.
Therefore
,
a
study
was
carried
out
to
evaluate
the
efficacy
of
spirulina
as
an
antioxidant
adjuvant
to
corticosteroid
injections
in
the
management
of
40
oral
submucous
fibrosis
subjects
of
south
Karnataka
and
north
Kerala
.
An
intervention
study
was
conducted
on
40
oral
submucous
fibrosis
cases
,
40
patients
were
divided
into
two
groups
,
group
A
(
spirulina
group
)
and
group
B
(
placebo
group
)
.
Group
A
received
spirulina
500
mg
twice
daily
and
biweekly
intralesional
steroid
injection
of
Betamethasone
4
mg
/
ml
for
3
months
and
group
B
was
given
placebo
capsules
twice
daily
and
biweekly
intralesional
steroid
injection
of
Betamethasone
4
mg
/
ml
for
3
months
.
The
results
were
analyzed
with
the
paired
"
t
"
test
and
the
unpaired
"
t
"
test
.
Clinical
improvements
in
mouth
opening
was
significant
in
the
posttreatment
period
in
both
Spirulina
and
placebo
groups
.
Both
the
groups
showed
statistically
significant
reduction
in
burning
sensation
.
However
,
when
both
groups
were
compared
,
mouth
opening
and
burning
sensation
was
found
to
be
statistically
very
highly
significant
in
favor
of
the
spirulina
group
.
Spirulina
can
bring
about
clinical
improvements
in
OSF
patients
.
The
observed
effects
suggest
that
spirulina
can
be
used
as
an
adjuvant
therapy
in
the
initial
management
of
OSF
patients
.
However
,
studies
involving
larger
samples
and
longer
period
of
treatment
follow
up
are
suggested
in
the
future
.
