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Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis.
[oral submucous fibrosis]
Definitive
therapy
is
not
defined
for
the
management
of
oral
submucous
fibrosis
(
OSMF
)
.
This
study
evaluated
the
efficacy
of
aloe
vera
gel
as
an
adjuvant
treatment
of
OSMF
.
A
double
-blind
,
placebo-controlled
,
parallel-group
randomized
controlled
trial
was
conducted
on
60
subjects
with
OSMF
divided
into
medicinal
treatment
(
submucosal
injection
of
hyaluronidase
and
dexamethasone
,
n
=
30
)
and
surgical
treatment
(
n
=
30
)
categories
.
Each
category
was
randomly
divided
into
groups
A
(
with
aloe
vera
,
n
=
15
per
category
)
and
B
(
without
aloe
vera
,
n
=
15
per
category
)
.
Follow-up
assessment
for
various
symptoms
was
performed
,
and
results
were
analyzed
using
paired
and
unpaired
Student
t
tests
.
The
group
receiving
aloe
vera
had
a
significant
improvement
in
most
symptoms
of
OSMF
(
P
<
.
01
)
compared
with
the
non-aloe
vera
group
,
in
both
the
medicinal
and
surgical
categories
.
Aloe
vera
gel
was
effective
as
an
adjuvant
in
treatment
of
OSMF
.
