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Quantitative estimation of Serum Fibrinogen Degradation Product levels in Oral Premalignant and Malignant lesions.
[oral submucous fibrosis]
A
specific
association
between
cancer
and
the
hemostatic
system
has
been
recognized
for
decades
.
Fibrinogen
degradation
product
(
FDP
)
is
one
of
the
factors
,
which
opposes
coagulation
causing
fibrinolysis
.
The
mechanism
of
fibrinolysis
can
be
used
by
the
malignant
cells
to
facilitate
invasion
into
surrounding
tissues
and
metastases
to
distant
organs
by
breaking
the
fibrin
barrier
.
The
coagulation
cascade
also
plays
an
important
role
in
both
the
formation
of
tumour
stroma
and
the
promotion
of
hematogenous
metastasis
.
The
present
study
was
undertaken
to
evaluate
the
serum
FDP
levels
in
individuals
without
any
oral
lesions
and
those
with
oral
premalignant
and
malignant
lesions
,
and
determine
whether
the
estimation
of
the
same
can
be
used
as
an
aid
in
early
diagnosis
.
25
cases
each
of
Leukoplakia
,
Oral
submucous
fibrosis
and
Oral
squamous
cell
carcinomas
(
OSCC
)
and
normal
control
cases
were
selected
.
The
OSCC
cases
were
staged
according
to
the
TNM
classification
.
Diagnosis
of
all
cases
was
confirmed
by
histopathological
examination
.
The
aspirated
serum
was
then
subjected
to
the
Thrombo-
Wellco
test
which
was
used
for
the
biochemical
analysis
of
FDP
.
I
ncreased
serum
FDP
levels
were
seen
corresponding
to
the
stage
of
the
OSCC
,
but
no
appreciable
difference
was
noted
between
the
histological
grades
or
in
cases
of
premalignant
lesions
.
The
study
demonstrates
that
FDP
levels
correlate
with
the
cancer
stage
and
progression
.
Thus
,
the
estimation
of
serum
FDP
levels
can
be
used
as
a
reliable
prognostic
indicator
and
as
a
biologic
marker
of
tumour
spread
How
to
cite
this
article
:
Gharat
L
,
Rathod
GP
.
Quantitative
estimation
of
Serum
Fibrinogen
Degradation
Product
levels
in
Oral
Premalignant
and
Malignant
lesions
.
J
Int
Oral
Health
2013
;
5
(
5
)
:
65
-
72
.
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