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Alteration in plasma lipid profile in oral submucous fibrosis patients: A case control study.
[oral submucous fibrosis]
Lipids
are
major
cell
membrane
components
essential
for
various
biological
functions
including
cell
growth
and
division
of
normal
and
malignant
tissue
.
They
are
also
required
for
maintenance
of
structural
and
functional
integrity
of
all
biological
membranes
.
Alteration
in
the
plasma
lipid
profile
has
been
associated
with
a
variety
of
cancers
and
precancerous
conditions
including
those
of
the
head
and
neck
region
.
The
present
study
aimed
to
evaluate
the
alteration
in
plasma
lipid
profile
in
oral
submucous
fibrosis
(
OSF
)
patients
.
A
total
of
30
patients
were
included
in
the
study
,
20
with
oral
submucous
fibrosis
and
10
healthy
controls
.
Fasting
plasma
lipid
profile
including
Total
Cholesterol
(
TC
)
,
Very
Low
Density
Lipoproteins
(
VLDL
)
,
Low
Density
Lipoproteins
(
LDL
)
,
High
Density
Lipoproteins
(
HDL
)
and
Tri
-
Glycerides
(
TG
)
were
measured
using
semiautomatic
analyser
.
The
data
obtained
were
analysed
using
independent
sample
'
t
'
test
.
A
statistically
significant
decrease
in
plasma
total
cholesterol
,
LDL
and
HDL
was
observed
in
patients
with
OSMF
as
compared
to
the
controls
,
but
it
was
not
statistically
significant
for
VLDL
and
TG
values
.
The
results
of
the
present
study
show
that
there
is
an
inverse
relationship
between
lipid
profile
and
the
presence
of
oral
submucous
fibrosis
.
Hence
,
alteration
in
plasma
lipid
profile
may
have
a
diagnostic
role
in
the
future
and
can
be
used
as
a
biochemical
indicator
to
detect
the
initial
changes
seen
in
the
neoplastic
process
.
