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The association between miR-499a polymorphism and oral squamous cell carcinoma progression.
[oral submucous fibrosis]
To
investigate
the
association
of
miR-
499
a
genetic
polymorphism
with
the
risk
of
oral
leukoplakia
,
oral
submucous
fibrosis
(
OSF
)
,
oral
squamous
cell
carcinoma
(
OSCC
)
,
and
clinicopathological
outcomes
of
OSCC
.
T
he
genotyping
of
miR-
499
a
T
>
C
(
rs
3746444
)
using
TagMan
assay
was
conducted
in
two
case-control
studies
of
1549
subjects
.
miR-
499
a-
5
p
and
miR-
499
a-
3
p
were
assayed
using
stem-loop
RT-PCR
for
63
paired
OSCC
and
adjacent
normal
tissues
.
T
/
C
+
C
/
C
genotypes
[
adjusted
odds
ratio
(
AOR
)
1
.
84
,
P
Â
=
Â
0
.
032
]
and
C
allelic
type
(
AOR
1
.
91
,
P
Â
=
Â
0
.
007
)
at
miR-
499
a
T
>
C
were
associated
with
an
increased
risk
of
BQ-related
OSF
as
compared
to
those
with
T
/
T
genotype
or
T
allelic
type
,
respectively
.
Conversely
,
T
/
C
+
C
/
C
genotypes
and
C
allelic
type
decreased
the
risk
of
OSCC
,
especially
for
non-
BQ-related
OSCC
(
for
genotype
:
AOR
0
.
49
,
P
Â
=
Â
0
.
010
;
for
allelic
type
:
AOR
0
.
50
,
P
Â
=
Â
0
.
007
)
.
Additionally
,
downregulation
of
miR-
499
a-
5
p
was
found
in
OSCC
tissues
(
P
Â
=
Â
0
.
001
)
and
correlated
with
the
TT
genotype
(
P
Â
=
Â
0
.
001
)
.
The
T
/
C
+
C
/
C
genotypes
of
MiR-
499
a
may
contribute
to
an
increased
risk
of
BQ-related
OSF
,
but
a
decreased
risk
of
OSCC
.
miR-
499
a
T
>
C
influences
the
expression
levels
of
miR-
499
a-
5
p
during
the
tumorigenesis
of
OSCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
