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Littoral cell angioma: review of the literature and case report.
[alpha-thalassemia]
Littoral
cell
angioma
(
LCA
)
,
a
primary
vascular
neoplasm
originating
from
splenic
red
pulp
littoral
cells
,
was
initially
thought
to
be
an
extremely
rare
pathology
.
There
have
been
an
increasing
number
of
cases
reported
in
the
literature
.
However
,
the
etiology
and
prevalence
of
LCA
is
still
unclear
,
partly
due
to
the
rarity
of
cases
.
The
association
of
LCA
with
internal
organ
cancers
,
specifically
lymphoma
,
has
also
been
reported
.
In
the
patients
with
a
history
of
cancer
/
lymphoma
,
the
accurate
diagnosis
of
LCA
as
the
cause
of
the
splenomegaly
is
challenging
.
Here
we
present
a
case
of
LCA
in
a
patient
with
non-
Hodgkin
B-
cell
lymphoma
and
alpha-thalassemia
trait
.
To
our
knowledge
,
this
is
the
first
report
of
the
coexistence
of
LCA
and
thalassemia
and
only
the
second
report
of
LCA
and
marginal-zone
non-
Hodgkin
B-
cell
lymphoma
.
We
review
the
literature
and
discuss
the
radiologic
and
pathologic
findings
of
this
case
compared
with
the
previously
reported
cases
.
Diseases
Validation
Diseases presenting
"the rarity of cases"
symptom
alpha-thalassemia
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