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Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
[oral submucous fibrosis]
Mast
cells
(
MCs
)
expressing
serine
proteases
;
tryptase
and
chymase
,
are
associated
with
fibrosis
in
various
diseases
.
However
,
little
is
known
about
their
involvement
in
oral
submucous
fibrosis
(
OSF
)
.
Our
goal
was
to
evaluate
the
role
of
MC
tryptase
and
chymase
in
the
pathogenesis
of
OSF
and
its
malignant
transformation
.
Immunohistochemical
expression
of
MC
tryptase
and
chymase
was
evaluated
in
20
cases
of
OSF
,
10
cases
of
oral
squamous
cell
carcinoma
(
OSCC
)
and
10
cases
of
healthy
controls
.
Subepithelial
zone
of
Stage
1
and
2
while
deep
zone
of
Stage
3
and
4
OSF
demonstrated
increased
tryptase
positive
MCs
.
OSCC
revealed
a
proportionate
increase
in
tryptase
and
chymase
positive
MCs
irrespective
of
areas
of
distribution
.
An
altered
balance
in
the
subepithelial
and
deep
distribution
of
tryptase
and
chymase
positive
MCs
play
an
important
role
in
the
pathogenesis
of
OSF
and
its
malignant
transformation
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
