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Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
[oral submucous fibrosis]
Mast
cells
(
MCs
)
expressing
serine
proteases
;
tryptase
and
chymase
,
are
associated
with
fibrosis
in
various
diseases
.
However
,
little
is
known
about
their
involvement
in
oral
submucous
fibrosis
(
OSF
)
.
Our
goal
was
to
evaluate
the
role
of
MC
tryptase
and
chymase
in
the
pathogenesis
of
OSF
and
its
malignant
transformation
.
Immunohistochemical
expression
of
MC
tryptase
and
chymase
was
evaluated
in
20
cases
of
OSF
,
10
cases
of
oral
squamous
cell
carcinoma
(
OSCC
)
and
10
cases
of
healthy
controls
.
Subepithelial
zone
of
Stage
1
and
2
while
deep
zone
of
Stage
3
and
4
OSF
demonstrated
increased
tryptase
positive
MCs
.
OSCC
revealed
a
proportionate
increase
in
tryptase
and
chymase
positive
MCs
irrespective
of
areas
of
distribution
.
An
altered
balance
in
the
subepithelial
and
deep
distribution
of
tryptase
and
chymase
positive
MCs
play
an
important
role
in
the
pathogenesis
of
OSF
and
its
malignant
transformation
.
Diseases
Validation
Diseases presenting
"chymase positive mcs irrespective of areas of distribution"
symptom
oral submucous fibrosis
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