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Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSF
)
,
a
potentially
malignant
oral
lesion
,
is
a
form
of
pathological
fibrosis
affecting
the
oral
mucosa
.
It
results
from
an
imbalance
in
equilibrium
of
the
normal
process
of
synthesis
and
degradation
of
extra
cellular
matrix
.
Matrix
metalloproteinases
and
its
inhibitors
play
important
role
in
remodeling
of
the
extra
cellular
matrix
which
are
important
in
progression
and
pathogenesis
of
potentially
malignant
lesions
to
malignancy
.
To
evaluate
the
expression
and
distribution
of
Matrix
metalloproteinases-
2
(
MMP-
2
)
and
Tissue
inhibitor
of
metalloproteinases-
2
(
TIMP-
2
)
in
different
grades
of
Oral
Submucous
Fibrosis
(
OSF
)
.
Immunohistochemical
analysis
for
MMP-
2
and
its
TIMP-
2
was
performed
in
30
histopathologically
confirmed
,
formalin
fixed
,
paraffin
embedded
specimens
of
OSF
.
A
semi-quantitative
analysis
was
done
to
assess
the
expression
,
distribution
and
comparison
of
these
in
various
stages
of
this
disease
.
All
moderately
advanced
cases
and
64
.
2
%
for
MMP-
2
and
78
.
5
%
for
TIMP-
2
of
early
stage
cases
showed
positivity
.
Between
two
stages
of
OSF
,
statistically
significant
differences
were
noted
in
expression
of
TIMP-
2
in
lamina
propria
,
deep
connective
tissue
and
supra
basal
layers
(
p
<
0
.
05
)
and
basal
and
supra
basal
layers
for
MMP-
2
(
p
<
0
.
05
)
.
The
simultaneous
increase
in
expression
of
MMP-
2
and
TIMP-
2
with
advancing
stages
of
OSF
can
provide
a
basis
for
considering
the
proteases
as
important
mediators
in
the
pathogenesis
and
progression
of
OSF
which
could
aid
in
identifying
the
aggressiveness
of
the
condition
and
elucidate
its
role
in
its
malignant
transformation
.
