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HBO: a possible supplementary therapy for oral potentially malignant disorders.
[oral submucous fibrosis]
Oral
potentially
malignant
disorders
(
OPMDs
)
are
chronic
inflammatory
diseases
in
which
cells
suffer
hypoxia
referring
to
deprivation
of
adequate
oxygen
supply
.
Hyperbaric
oxygen
treatment
(
HBO
)
,
which
can
increase
oxygen
tension
and
delivery
to
oxygen-
deficient
tissue
,
is
a
supplementary
therapy
to
improve
or
cure
disorders
involving
hypoxia
.
Although
the
applications
of
HBO
in
wound
healings
,
acute
ischemic
stroke
,
radiation-induced
soft
tissue
injury
and
cancers
are
extensively
reported
,
there
are
only
few
studies
on
their
effect
in
OPMDs
.
Not
only
does
HBO
furnish
oxygen-
it
also
possesses
potent
anti-
inflammatory
properties
.
At
the
cellular
level
,
HBO
can
decrease
lymphocyte
proliferation
and
promote
apoptosis
of
fibroblasts
.
At
the
molecular
level
,
it
can
decrease
expression
of
HIF
,
ICAM-
1
,
TNF
-α
,
TGF-β
,
and
IFN-γ
,
as
well
as
increase
vascular
VEGF
expression
and
angiogenesis
.
Thus
,
we
hypothesize
that
HBO
may
contribute
to
treat
OPMDs
,
including
oral
lichen
planus
,
oral
leukoplakia
,
and
oral
submucous
fibrosis
both
at
the
cellular
level
and
the
molecular
level
,
and
that
it
would
be
a
safe
and
inexpensive
therapeutic
strategy
.
Diseases
Validation
Diseases presenting
"ischemic stroke"
symptom
adrenal incidentaloma
alpha-thalassemia
cadasil
fabry disease
locked-in syndrome
oral submucous fibrosis
pyruvate dehydrogenase deficiency
sneddon syndrome
zellweger syndrome
This symptom has already been validated