Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
HBO: a possible supplementary therapy for oral potentially malignant disorders.
[oral submucous fibrosis]
Oral
potentially
malignant
disorders
(
OPMDs
)
are
chronic
inflammatory
diseases
in
which
cells
suffer
hypoxia
referring
to
deprivation
of
adequate
oxygen
supply
.
Hyperbaric
oxygen
treatment
(
HBO
)
,
which
can
increase
oxygen
tension
and
delivery
to
oxygen-
deficient
tissue
,
is
a
supplementary
therapy
to
improve
or
cure
disorders
involving
hypoxia
.
Although
the
applications
of
HBO
in
wound
healings
,
acute
ischemic
stroke
,
radiation-induced
soft
tissue
injury
and
cancers
are
extensively
reported
,
there
are
only
few
studies
on
their
effect
in
OPMDs
.
Not
only
does
HBO
furnish
oxygen-
it
also
possesses
potent
anti-
inflammatory
properties
.
At
the
cellular
level
,
HBO
can
decrease
lymphocyte
proliferation
and
promote
apoptosis
of
fibroblasts
.
At
the
molecular
level
,
it
can
decrease
expression
of
HIF
,
ICAM-
1
,
TNF
-α
,
TGF-β
,
and
IFN-γ
,
as
well
as
increase
vascular
VEGF
expression
and
angiogenesis
.
Thus
,
we
hypothesize
that
HBO
may
contribute
to
treat
OPMDs
,
including
oral
lichen
planus
,
oral
leukoplakia
,
and
oral
submucous
fibrosis
both
at
the
cellular
level
and
the
molecular
level
,
and
that
it
would
be
a
safe
and
inexpensive
therapeutic
strategy
.
Diseases
Validation
Diseases presenting
"only few studies"
symptom
cholangiocarcinoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
oral submucous fibrosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom