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Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
a
chronic
fibrotic
disorder
in
which
the
degree
of
vascularity
has
always
been
a
matter
of
dispute
;
however
,
morphological
studies
of
the
blood
vessels
in
OSMF
have
been
sparse
.
This
study
was
performed
to
assess
the
mucosal
vasculature
in
normal
oral
mucosa
,
early
and
advanced
OSMF
,
and
well
differentiated
squamous
cell
carcinoma
(
WDSCC
)
using
morphometry
.
The
study
included
histologically
diagnosed
cases
of
early
(
n
=
30
)
and
advanced
(
n
=
30
)
OSMF
,
and
WDSCC
(
n
=
30
)
,
with
normal
oral
mucosa
(
n
=
10
)
as
a
control
.
Morphometric
image
analysis
of
blood
vessels
was
performed
on
H
&
E
-
stained
sections
for
evaluation
of
vascular
density
,
vascular
luminal
diameter
,
area
and
percentage
area
.
A
significant
increase
in
all
of
the
parameters
was
noted
in
the
test
groups
relative
to
the
controls
.
The
mean
vascular
density
and
mean
vascular
percentage
area
were
significantly
increased
in
early
OSMF
and
WDSCC
relative
to
controls
,
and
also
in
advanced
OSMF
and
WDSCC
in
comparison
with
early
OSMF
.
The
vascularity
increased
progressively
from
normal
to
premalignancy
and
malignancy
,
emphasizing
the
importance
of
angiogenesis
in
tumor
development
and
progression
.
The
vascularity
was
increased
in
early
OSMF
and
reduced
in
advanced
OSMF
,
suggesting
that
inflammation
may
play
a
role
in
the
early
stages
while
progressive
fibrosis
may
predispose
to
atrophy
of
the
epithelium
and
subsequent
malignant
changes
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated