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Morphometric analysis of the mucosal vasculature in oral submucous fibrosis and its comparison with oral squamous cell carcinoma.
[oral submucous fibrosis]
Oral
submucous
fibrosis
(
OSMF
)
is
a
chronic
fibrotic
disorder
in
which
the
degree
of
vascularity
has
always
been
a
matter
of
dispute
;
however
,
morphological
studies
of
the
blood
vessels
in
OSMF
have
been
sparse
.
This
study
was
performed
to
assess
the
mucosal
vasculature
in
normal
oral
mucosa
,
early
and
advanced
OSMF
,
and
well
differentiated
squamous
cell
carcinoma
(
WDSCC
)
using
morphometry
.
The
study
included
histologically
diagnosed
cases
of
early
(
n
=
30
)
and
advanced
(
n
=
30
)
OSMF
,
and
WDSCC
(
n
=
30
)
,
with
normal
oral
mucosa
(
n
=
10
)
as
a
control
.
Morphometric
image
analysis
of
blood
vessels
was
performed
on
H
&
E
-
stained
sections
for
evaluation
of
vascular
density
,
vascular
luminal
diameter
,
area
and
percentage
area
.
A
significant
increase
in
all
of
the
parameters
was
noted
in
the
test
groups
relative
to
the
controls
.
The
mean
vascular
density
and
mean
vascular
percentage
area
were
significantly
increased
in
early
OSMF
and
WDSCC
relative
to
controls
,
and
also
in
advanced
OSMF
and
WDSCC
in
comparison
with
early
OSMF
.
The
vascularity
increased
progressively
from
normal
to
premalignancy
and
malignancy
,
emphasizing
the
importance
of
angiogenesis
in
tumor
development
and
progression
.
The
vascularity
was
increased
in
early
OSMF
and
reduced
in
advanced
OSMF
,
suggesting
that
inflammation
may
play
a
role
in
the
early
stages
while
progressive
fibrosis
may
predispose
to
atrophy
of
the
epithelium
and
subsequent
malignant
changes
.
Diseases
Validation
Diseases presenting
"atrophy of the epithelium"
symptom
oral submucous fibrosis
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