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Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
,
a
potentially
premalignant
condition
for
oral
squamous
cell
carcinoma
,
manifests
both
non-
dysplastic
and
dysplastic
grades
.
Early
and
specific
identification
of
its
malignant
potentiality
suffers
from
diagnostic
limitations
that
may
be
addressed
by
correlated
molecular
pathology
attributes
having
histopathological
backdrop
.
Present
study
correlates
expressional
alteration
in
prime
epithelial
marker
E
-
cadherin
,
with
neo-angiogenic
molecules
viz
.
VEGF
and
CD
105
for
elucidation
of
malignant
potentiality
in
different
stages
of
oral
submucous
fibrosis
.
Sixty
-
eight
incision
biopsies
from
normal
oral
mucosa
(
n
=
10
)
,
non-
dysplastic
(
n
=
18
)
and
different
dysplastic
grades
(
n
=
40
)
of
oral
submucous
fibrosis
were
semi-quantitatively
analyzed
for
immunohistochemical
expressions
of
E
-
cadherin
(
membranous
and
cytoplasmic
)
,
VEGF
and
CD
105
which
were
further
statistically
correlated
.
The
loss
of
membranous
E
-
cadherin
with
increase
in
cytoplasmic
accumulation
in
differentiative
layers
of
epithelium
through
the
progression
of
dysplasia
was
noted
along
with
up-regulation
in
VEGF
expressions
.
The
number
of
CD
105
(
+
)
blood
vessels
and
their
major
axis
also
showed
significant
increase
from
non-dysplasia
toward
higher
grades
of
dysplasia
.
The
positive
correlation
between
deregulated
expression
of
epithelial
cell-cell
adhesion
molecule
and
increase
in
neo-angiogenic
attributes
of
oral
submucous
fibrosis
with
increase
in
dysplastic
grades
indicated
elucidatory
potential
of
molecular
expression
features
in
assessment
of
malignant
potentiality
in
oral
submucous
fibrosis
.
Diseases
Validation
Diseases presenting
"blood vessels"
symptom
cadasil
coats disease
cushing syndrome
esophageal adenocarcinoma
hereditary cerebral hemorrhage with amyloidosis
hydrocephalus with stenosis of the aqueduct of sylvius
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
oral submucous fibrosis
pyomyositis
sneddon syndrome
von hippel-lindau disease
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