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Correlated analysis of semi-quantitative immunohistochemical features of E-cadherin, VEGF and CD105 in assessing malignant potentiality of oral submucous fibrosis.
[oral submucous fibrosis]
Oral
submucous
fibrosis
,
a
potentially
premalignant
condition
for
oral
squamous
cell
carcinoma
,
manifests
both
non-
dysplastic
and
dysplastic
grades
.
Early
and
specific
identification
of
its
malignant
potentiality
suffers
from
diagnostic
limitations
that
may
be
addressed
by
correlated
molecular
pathology
attributes
having
histopathological
backdrop
.
Present
study
correlates
expressional
alteration
in
prime
epithelial
marker
E
-
cadherin
,
with
neo-angiogenic
molecules
viz
.
VEGF
and
CD
105
for
elucidation
of
malignant
potentiality
in
different
stages
of
oral
submucous
fibrosis
.
Sixty
-
eight
incision
biopsies
from
normal
oral
mucosa
(
n
=
10
)
,
non-
dysplastic
(
n
=
18
)
and
different
dysplastic
grades
(
n
=
40
)
of
oral
submucous
fibrosis
were
semi-quantitatively
analyzed
for
immunohistochemical
expressions
of
E
-
cadherin
(
membranous
and
cytoplasmic
)
,
VEGF
and
CD
105
which
were
further
statistically
correlated
.
The
loss
of
membranous
E
-
cadherin
with
increase
in
cytoplasmic
accumulation
in
differentiative
layers
of
epithelium
through
the
progression
of
dysplasia
was
noted
along
with
up-regulation
in
VEGF
expressions
.
The
number
of
CD
105
(
+
)
blood
vessels
and
their
major
axis
also
showed
significant
increase
from
non-dysplasia
toward
higher
grades
of
dysplasia
.
The
positive
correlation
between
deregulated
expression
of
epithelial
cell-cell
adhesion
molecule
and
increase
in
neo-angiogenic
attributes
of
oral
submucous
fibrosis
with
increase
in
dysplastic
grades
indicated
elucidatory
potential
of
molecular
expression
features
in
assessment
of
malignant
potentiality
in
oral
submucous
fibrosis
.
Diseases
Validation
Diseases presenting
"manifests both non-dysplastic and dysplastic grades"
symptom
oral submucous fibrosis
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