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Evaluation of lactate dehydrogenase enzyme activity in saliva and serum of oral submucous fibrosis patients.
[oral submucous fibrosis]
Of
all
oral
precancerous
conditions
,
Oral
Submucous
Fibrosis
is
of
greater
concern
because
of
its
disabling
nature
and
relative
greater
chances
of
malignant
transformation
.
This
malignant
transformation
involves
glycolytic
pathways
that
can
alter
lactate
dehydrogenase
levels
.
Therefore
the
aim
of
this
study
was
to
estimate
the
LDH
levels
in
saliva
and
serum
of
subjects
with
OSMF
and
to
compare
them
with
healthy
controls
and
to
correlate
the
relationship
between
pathogenesis
of
OSMF
and
the
LDH
enzyme
.
S
ixty
Subjects
were
recruited
for
this
study
and
divided
into
two
groups
,
30
subjects
with
OSMF
(
Group
A
)
and
30
healthy
controls
(
Group
B
)
.
Venous
blood
and
unstimulated
whole
saliva
measuring
1
ml
was
collected
from
each
of
these
evaluated
for
LDH
levels
using
the
standard
kit
method
.
The
data
obtained
were
subjected
to
statistical
analysis
using
the
SPSS
software
version
17
.
The
average
salivary
LDH
value
for
Group
A
was
606
.
83
±
60
.
09
U
/
l
and
for
Group
B
was
80
.
73
±
20
.
06
U
/
l
.
salivary
LDH
was
greater
in
group
A
than
Group
B
and
this
was
statistically
significant
.
On
comparing
the
serum
and
salivary
LDH
in
Group
A
with
the
clinical
staging
of
OSMF
,
the
results
were
not
statistically
significant
.
Similarly
no
statistically
significant
relationship
was
found
on
comparing
the
serum
and
salivary
LDH
in
Group
A
(
OSMF
subjects
)
with
duration
of
habit
.
This
study
provides
additional
rationale
for
the
role
of
salivary
LDH
in
the
early
diagnosis
and
prognosis
of
oral
submucous
fibrosis
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
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dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
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esophageal squamous cell carcinoma
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familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
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phenylketonuria
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proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
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systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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