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Estimation of serum superoxide dismutase and serum malondialdehyde in oral submucous fibrosis: A clinical and biochemical study.
[oral submucous fibrosis]
To
estimate
the
level
of
lipid
peroxidation
product
(
MDA
)
and
the
activities
of
antioxidative
enzymes
superoxide
dismutase
(
SOD
)
and
the
correlation
of
these
parameters
in
Oral
Submucous
fibrosis
(
OSF
)
.
Estimation
of
MDA
and
SOD
levels
in
OSF
patients
and
controls
.
Patients
above
15
years
of
age
,
who
were
diagnosed
as
OSF
based
upon
thorough
history
,
clinical
examination
and
histopathological
examination
without
any
underlying
systemic
diseases
,
were
included
in
the
present
study
.
Equal
number
of
healthy
subjects
without
any
deleterious
habits
and
without
any
clinically
obvious
oral
lesions
or
systemic
diseases
were
selected
as
the
control
group
.
The
estimation
of
MDA
in
serum
was
done
by
thiobarbituric
acid
reactive
species
method
.
SOD
was
assayed
by
inhibition
and
autoxidation
of
adrenaline
method
.
The
data
were
analyzed
with
Student
's
t-test
.
Comparison
of
MDA
,
SOD
among
the
OSF
group
and
control
group
showed
statistically
significant
increased
levels
of
malondialdehyde
and
decreased
levels
of
superoxide
dismutase
among
the
OSF
groups
.
Significant
changes
were
not
seen
in
MDA
and
SOD
levels
between
the
different
grades
of
OSF
.
F
rom
the
present
study
,
estimation
of
lipid
peroxidation
like
MDA
was
done
,
which
showed
increased
levels
in
the
OSF
group
compared
to
the
control
group
and
antioxidant
enzyme
levels
like
SOD
showed
decreased
levels
in
the
OSF
group
compared
to
the
control
group
.
These
can
be
considered
as
a
subject
of
interest
for
their
possible
role
in
many
of
the
precancerous
and
cancerous
conditions
.
