Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in northern Thailand.

[alpha-thalassemia]

There have been no reports for the frequency of Hb Q-Thailand [alpha 74 (EF 3 )Asp --> His , GAC > CAC ] and its combinations either with other forms of thalassemia or hemoglobinopathies in Northern Thailand . The aims of this study were to search for Hb Q-Thailand and its combinations in Northern Thai population and to analyze fractions of hemoglobin in Hb Q-Thailand and its combinations on high performance liquid chromatography (HPLC ) chromatograms and /or capillary electrophoresis (CE ) electrophoregrams .Blood samples from public and private hospitals in 7 northern provinces of Thailand were analyzed for thalassemia and hemoglobinopathy diagnoses using HPLC and /or CE and DNA analysis techniques at the Thalassemia Laboratory , Associated Medical Sciences Clinical Service Center , Chiang Mai , Thailand .Hb Q-Thailand was found in 13 of 13 ,596 (0 .10 %) samples ; 6 were heterozygous Hb Q-Thailand , 4 were compound Hb Q-Thailand /alpha-thalassemia -1 Southeast Asian (SEA ) type deletion and 3 with combinations of Hb Q-Thailand /beta (0 )-thalassemia , Hb Q-Thailand /Hb E and Hb Q-Thailand /Hb E /alpha-thalassemia -1 SEA type deletion . The fractions of hemoglobin on HPLC chromatograms and CE electrophoregrams were observed based on types of combinations .Hb Q-Thailand and its combinations could be found in northern Thai population with the frequency of 0 .10 %. Thus , the better understanding of HPLC chromatogram and /or CE electrophoregram patterns of Hb Q-Thailand and its combination is essential for diagnosis and genetic counseling of thalassemia and hemoglobinopathies in this area .

Diseases
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Diseases presenting "type deletion" symptom

alpha-thalassemia

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