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Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in northern Thailand.
[alpha-thalassemia]
There
have
been
no
reports
for
the
frequency
of
Hb
Q-
Thailand
[
alpha
74
(
EF
3
)
Asp
-
-
>
His
,
GAC
>
CAC
]
and
its
combinations
either
with
other
forms
of
thalassemia
or
hemoglobinopathies
in
Northern
Thailand
.
The
aims
of
this
study
were
to
search
for
Hb
Q-
Thailand
and
its
combinations
in
Northern
Thai
population
and
to
analyze
fractions
of
hemoglobin
in
Hb
Q-
Thailand
and
its
combinations
on
high
performance
liquid
chromatography
(
HPLC
)
chromatograms
and
/
or
capillary
electrophoresis
(
CE
)
electrophoregrams
.
Blood
samples
from
public
and
private
hospitals
in
7
northern
provinces
of
Thailand
were
analyzed
for
thalassemia
and
hemoglobinopathy
diagnoses
using
HPLC
and
/
or
CE
and
DNA
analysis
techniques
at
the
Thalassemia
Laboratory
,
Associated
Medical
Sciences
Clinical
Service
Center
,
Chiang
Mai
,
Thailand
.
Hb
Q-
Thailand
was
found
in
13
of
13
,
596
(
0
.
10
%
)
samples
;
6
were
heterozygous
Hb
Q-
Thailand
,
4
were
compound
Hb
Q-
Thailand
/
alpha-thalassemia
-
1
Southeast
Asian
(
SEA
)
type
deletion
and
3
with
combinations
of
Hb
Q-
Thailand
/
beta
(
0
)
-
thalassemia
,
Hb
Q-
Thailand
/
Hb
E
and
Hb
Q-
Thailand
/
Hb
E
/
alpha-thalassemia
-
1
SEA
type
deletion
.
The
fractions
of
hemoglobin
on
HPLC
chromatograms
and
CE
electrophoregrams
were
observed
based
on
types
of
combinations
.
Hb
Q-
Thailand
and
its
combinations
could
be
found
in
northern
Thai
population
with
the
frequency
of
0
.
10
%
.
Thus
,
the
better
understanding
of
HPLC
chromatogram
and
/
or
CE
electrophoregram
patterns
of
Hb
Q-
Thailand
and
its
combination
is
essential
for
diagnosis
and
genetic
counseling
of
thalassemia
and
hemoglobinopathies
in
this
area
.
