Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Of Omenn and mice.
[omenn syndrome]
Omenn
syndrome
(
OS
)
is
a
peculiar
immunodeficiency
in
which
profound
T
and
B
cell
defects
are
associated
with
severe
autoimmune
manifestations
.
Although
the
molecular
and
biochemical
bases
of
OS
have
been
elucidated
,
the
mechanisms
leading
to
T
cell
infiltration
of
peripheral
tissues
such
as
skin
and
gut
still
remain
unsolved
.
Two
murine
models
with
hypomorphic
mutations
in
rag
genes
reproducing
OS
features
and
a
murine
model
of
lymphopenia
-derived
autoimmunity
with
similar
immunopathology
were
recently
described
.
The
aim
of
this
review
is
to
integrate
clues
regarding
the
roles
of
impaired
thymic
development
and
lymphopenia
into
the
pathogenesis
of
autoimmunity
.
Diseases
Validation
Diseases presenting
"b cell defects are associated with severe autoimmune manifestations"
symptom
omenn syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom