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ARKRAY ADAMS A1c HA-8180T Analyzer for Diagnosis of Thalassemia and Hemoglobinopathies Common in Southeast Asia.
[alpha-thalassemia]
To
evaluate
the
ARKRAY
ADAMS
A
1
c
HA-
8180
T
analyzer
for
diagnosis
of
thalassemias
and
hemoglobinopathies
commonly
found
in
the
Southeast
Asian
population
.
O
ur
cohort
consisted
of
557
specimens
from
adults
referred
for
thalassemia
diagnosis
.
From
these
,
we
selected
457
specimens
and
subjected
them
to
DNA
analysis
to
determine
various
thalassemia
genotypes
.
Also
,
to
confirm
the
reference
range
for
HbA
2
,
we
obtained
an
additional
48
specimens
from
healthy
individuals
.
We
estimated
the
diagnostic
range
for
Hb
E
from
specimens
from
another
52
subject
individuals
previously
diagnosed
with
heterozygous
HbE
.
All
of
these
individuals
had
negative
results
in
DNA
testing
for
all
common
α-thalassemia
alleles
found
in
Thailand
.
We
performed
hemoglobin
(
Hb
)
analysis
and
compared
the
results
with
those
we
derived
from
testing
the
CAPILLARYS
2
Flex
Piercing
device
.
We
defined
genotypes
via
by
DNA
analysis
.
Performance
evaluation
revealed
the
within-
and
between-run
precision
for
analysis
of
HbA
2
and
HbE
,
with
coefficients
of
variation
(
CVs
)
ranging
from
0
.
6
%
to
2
.
5
%
.
We
determined
the
reference
ranges
of
HbA
2
and
HbE
in
the
HbE
heterozygote
to
be
2
.
2
%
to
3
.
4
%
and
25
.
7
%
to
31
.
0
%
,
respectively
.
We
were
able
to
identify
all
cases
of
β-thalassemia
and
HbE
disorders
.
We
coeluted
HbH
and
Hb
Bart
and
interfered
with
acetylated
HbF
.
T
he
ARKRAY
ADAMS
A
1
c
HA-
8180
T
analyzer
could
accurately
identify
which
individuals
had
β-thalassemia
and
HbE
disorders
.
However
,
compared
with
other
high
-performance
liquid
chromatography
instruments
in
diagnosing
α-thalassemia
disease
with
HbH
and
Hb
Bart
,
this
analyzer
is
relatively
difficult
to
use
.
