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A random Abstract
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Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin.
[omenn syndrome]
Graft-versus-host
disease
is
uncommon
in
autologous
hematopoietic
cell
transplantation
(
HCT
)
and
is
typically
brief
and
mild
.
We
report
unusual
,
protracted
,
and
severe
Omenn
syndrome
-like
autoaggression
following
autologous
HCT
.
We
identified
a
profound
FOXP
3
(
+
)
regulatory
T
cell
defect
that
coincided
with
hyperinflammatory
T
cell
responses
which
were
reversible
with
rapamycin
in
vitro
.