Colorectal cancer and self-reported tooth agenesis.

[oligodontia]

Germline mutations in APC and AXIN 2 are both associated with colon neoplasia as well as anomalous dental development . We tested the hypothesis that congenitally missing teeth may occur more commonly in individuals diagnosed with colorectal cancer than in individuals without this diagnosis .Via a survey conducted on 1636 individuals with colorectal cancer (CRC ) and 2788 individuals with no colorectal cancer from the Colon Cancer Family Registry , self-reported information on congenitally missing teeth was collected . The frequency of missing teeth between cases and controls was compared using Pearson 's chi -squared test or Fisher 's exact test .4 .8 % of cases and 5 .7 % of controls reported having at least one missing tooth (p = 0 .20 ). When we stratified by recruitment site , gender , and mutation status where available , frequency of missing teeth was not statistically significantly different between cases and controls .This study did not provide support for there being a general predisposition to missing teeth among a large cohort of CRC patients . The study neither addresses nor excludes the possibility , however , that individuals presenting with notable hypodontia /oligodontia might still have an increased risk for colorectal neoplasia .

Diseases
Validation

Diseases presenting "neoplasia" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

aniridia

carcinoma of the gallbladder

cholangiocarcinoma

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dentin dysplasia

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

hodgkin lymphoma, classical

liposarcoma

lymphangioleiomyomatosis

neuralgic amyotrophy

oligodontia

oral submucous fibrosis

pleomorphic liposarcoma

primary effusion lymphoma

pyomyositis

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wolf-hirschhorn syndrome

This symptom has already been validated