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[Association between AXIN2 polymorphism and oligodontia].
[oligodontia]
To
explore
the
association
between
AXIN
2
polymorphism
and
oligodontia
in
Chinese
population
.
W
e
employed
97
individuals
diagnosed
with
sporadic
non-syndromic
oligodontia
and
200
healthy
control
subjects
.
Their
DNA
was
obtained
from
the
whole
blood
or
buccul
swap
samples
and
the
genotyping
was
performed
by
polymerase
chain
reaction
(
PCR
)
.
Significant
differences
were
observed
in
the
allele
and
genotype
frequencies
of
rs
145353986
of
AXIN
2
.
Distributions
of
genotypes
GG
,
GC
and
CC
of
rs
145353986
polymorphism
were
significantly
different
between
the
case
group
and
the
control
group
(
P
=
0
.
011
)
and
C
allelic
frequency
was
higher
in
the
case
group
(
P
=
0
.
002
)
.
These
data
demonstrate
an
association
between
rs
145353986
of
AXIN
2
and
non-syndromic
oligodondia
in
the
Chinese
population
.
Furthermore
,
AXIN
2
can
be
regarded
as
a
marker
gene
for
the
risk
of
tooth
agenesis
.
Diseases
Validation
Diseases presenting
"sporadic non-syndromic oligodontia"
symptom
oligodontia
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