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Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study.
[oligodontia]
Tooth
agenesis
is
one
of
the
most
common
congenital
anomalies
in
humans
.
However
,
the
etiology
of
tooth
agenesis
remains
largely
unclear
,
as
well
as
evidence
base
useful
for
genetic
counseling
.
Therefore
,
we
estimated
the
prevalence
and
sibling
recurrence
risk
,
and
investigated
agenetic
patterns
systematically
.
Tooth
agenesis
was
classified
into
two
subtypes
:
hypodontia
(
one
to
five
missing
teeth
)
and
oligodontia
(
six
or
more
missing
teeth
)
.
The
prevalence
of
these
two
subtypes
were
6
.
8
%
[
95
%
confidence
interval
(
CI
)
:
6
.
1
-
7
.
7
%
]
and
0
.
1
%
(
95
%
CI
:
0
.
04
-
0
.
3
%
)
,
respectively
,
and
sibling
recurrence
risk
of
these
were
24
.
5
%
(
95
%
CI
:
13
.
8
-
38
.
3
%
)
and
43
.
8
%
(
95
%
CI
:
26
.
4
-
62
.
3
%
)
,
respectively
.
This
result
suggests
that
the
severe
phenotype
,
oligodontia
,
might
be
mostly
transmitted
in
a
dominant
fashion
.
Using
a
simple
statistical
modeling
approach
,
our
data
were
found
to
be
consistent
with
a
bilateral
symmetry
model
,
meaning
that
there
was
equal
probability
of
missing
teeth
from
the
right
and
left
sides
.
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symptom
oligodontia
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