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Hereditary nonmelanoma skin cancer.
[oculocutaneous albinism]
Cutaneous
basal
and
squamous
cell
carcinomas
are
among
the
most
frequent
malignancies
in
the
white
population
,
with
the
annual
incidence
estimates
ranging
from
1
million
to
3
.
5
million
cases
in
the
United
States
.
These
tumors
can
occur
either
sporadically
or
in
the
context
of
hereditary
genodermatoses
with
cancer
predisposition
,
such
as
basal
cell
nevus
syndrome
,
xeroderma
pigmentosum
,
epidermolysis
bullosa
,
or
oculocutaneous
albinism
.
Different
genes
and
signaling
pathways
have
been
shown
to
play
a
central
role
in
the
development
and
growth
of
these
tumors
.
This
article
overviews
the
clinical
features
,
diagnostic
criteria
,
and
the
most
recent
data
on
genetic
routes
of
the
major
hereditary
syndromes
predisposed
to
the
development
of
nonmelanoma
skin
cancer
.