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A random Abstract
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Homology modelling and virtual screening of P-protein in a quest for novel antimelanogenic agent and In vitro assessments.
[oculocutaneous albinism]
An
adequate
knowledge
on
molecular
mechanism
of
melanogenesis
provides
an
opportunity
to
find
the
novel
molecular
targets
for
the
discovery
and
development
of
new
cosmetics
.
Among
various
genes
,
the
OCA
2
is
being
essential
for
proper
melanin
synthesis
,
and
mutation
or
deletion
of
this
gene
leads
to
oculocutaneous
albinism
type
2
.
Thus
,
for
this
study
,
the
product
of
this
gene
,
that
is
P-
protein
,
was
targeted
in
quest
for
novel
inhibitors
as
antimelanogenic
agents
.
Based
on
pattern
search
of
amino
acid
sequence
and
homology
analysis
,
the
protein
structure
was
modelled
.
The
role
of
this
protein
has
been
predicted
as
a
tyrosine
transporter
of
melanosomes
.
Thus
,
the
molecular
library
was
generated
on
the
basis
of
tyrosine
transporter
inhibitor
.
Based
on
the
dock
score
,
20
molecules
have
been
considered
as
putative
inhibitors
for
P-
protein
.
Among
these
compounds
,
five
molecules
(
compound
#
1
,
#
4
,
#
8
,
#
13
and
#
17
)
were
found
to
be
quite
effective
as
antimelanogenic
without
having
any
toxicity
.
Further
investigations
to
establish
the
mechanism
of
action
,
the
indirect
methods
such
as
tyrosinase
assay
,
analysis
for
eumelanin
and
pheomelanins
and
investigation
of
mRNA
levels
were
being
carried
out
.
The
results
from
the
studies
offered
a
new
lead
in
antimelanogenic
therapy
and
may
be
very
useful
for
further
optimization
work
in
developing
them
as
novel
depigmenting
agents
.
Diseases
Validation
Diseases presenting
"albinism"
symptom
aniridia
cystinuria
harlequin ichthyosis
oculocutaneous albinism
phenylketonuria
This symptom has already been validated