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Neuralgic amyotrophy associated with antibiotic therapy.
[neuralgic amyotrophy]
To
report
a
case
of
neuralgic
amyotrophy
associated
with
antibiotic
therapy
.
A
22
-
year
-old
male
with
cystic
fibrosis
had
been
nonadherent
to
treatment
for
4
years
;
when
he
returned
to
the
clinic
with
symptoms
,
his
forced
expiratory
volume
in
1
second
dropped
from
84
%
predicted
to
43
%
predicted
.
He
was
admitted
to
the
hospital
for
treatment
after
failing
to
improve
on
oral
ciprofloxacin
and
inhaled
tobramycin
.
Treatment
was
initiated
with
intravenous
tobramycin
560
mg
daily
and
piperacillin
/
tazobactam
4
.
5
g
infused
every
6
hours
.
He
continued
inhaled
tobramycin
300
mg
twice
daily
,
his
home
doses
of
pancreatic
replacement
enzymes
and
vitamins
,
albuterol
2
.
5
mg
by
high
flow
nebulizer
(
HFN
)
4
times
daily
,
and
dornase
alpha
2
.
5
by
HFN
daily
.
Sputum
cultures
were
positive
for
methicillin-resistant
Staphylococcus
aureus
,
and
intravenous
vancomycin
1
g
every
8
hours
was
added
to
the
treatment
regimen
on
hospital
day
7
.
The
patient
developed
bilateral
shoulder
pain
followed
by
decreased
function
of
his
upper
extremities
2
days
later
.
He
was
treated
with
oral
ibuprofen
600
mg
every
6
h
and
oral
cyclobenzaprine
5
mg
daily
,
which
improved
his
pain
,
but
the
shoulder
stiffness
remained
throughout
his
hospital
stay
and
persisted
for
2
months
following
discharge
.
These
symptoms
resolved
but
recurred
rapidly
(
within
24
h
)
and
were
more
debilitating
following
a
second
exposure
to
the
same
antibiotics
at
the
same
doses
8
months
later
when
the
patient
was
readmitted
for
treatment
of
another
cystic
fibrosis
-related
pulmonary
exacerbation
.
To
our
knowledge
,
this
is
the
first
case
report
illustrating
neuralgic
amyotrophy
triggered
by
exposure
to
the
antibiotics
vancomycin
,
tobramycin
,
and
piperacillin
/
tazobactam
.
After
analysis
of
the
case
,
ruling
out
other
possibilities
and
using
the
Naranjo
probability
scale
,
we
found
that
there
is
a
highly
probable
likelihood
that
the
symptoms
presented
by
our
patient
were
secondary
to
his
drug
therapy
.
Neuralgic
amyotrophy
is
a
rare
condition
of
unknown
etiology
that
has
never
before
been
associated
with
administration
of
these
antibiotics
,
individually
or
in
combination
.
Because
of
the
specifics
of
the
clinical
history
,
we
were
unable
to
ascertain
whether
this
complication
was
due
to
a
single
antibiotic
or
to
the
combination
.
It
is
quite
possible
that
vancomycin
was
the
only
culprit
,
but
impossible
to
ensure
with
the
available
evidence
.
Clinicians
should
be
aware
of
this
adverse
reaction
when
facing
similar
complex
neurologic
symptoms
in
patients
who
are
receiving
the
antibiotic
treatment
described
here
,
especially
vancomycin
.
Diseases
Validation
Diseases presenting
"pain"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
aniridia
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
scrub typhus
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
trochlear dysplasia
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wolf-hirschhorn syndrome
This symptom has already been validated