Rare Diseases Symptoms Automatic Extraction

[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].

[neuralgic amyotrophy]

Cytoskeletal polymers play pleiotropic roles in neuroglial morphogenesis, intracellular transport, organization of pre- and post-synaptic scaffolds, etc. Thus, neuroglial dysfunction and degeneration are often accompanied by abnormalities in microtubules, actin and/or intermediate filament systems. Although our understanding of an unconventional cytoskeletal system composed of the septin family of GTP-binding proteins is far behind, recent studies have been revealing that qualitative and/or quantitative abnormalities of septins are also associated with neurodegenerative disorders including hereditary neuralgic amyotrophy, Parkinson disease, schizophrenia and bipolar disorder. A better understanding of the physiological and pathophysiological roles of the septin system should help develop useful biomarkers and therapeutic strategies for these diseases.

Diseases presenting "neurodegenerative disorders including hereditary neuralgic amyotrophy" symptom

  • neuralgic amyotrophy

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