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Septins in the glial cells of the nervous system.
[neuralgic amyotrophy]
The
capacity
of
cytoskeletal
septins
to
mediate
diverse
cellular
processes
is
related
to
their
ability
to
assemble
as
distinct
heterooligomers
and
higher
order
structures
.
However
,
in
many
cell
types
the
functional
relevance
of
septins
is
not
well
understood
.
This
minireview
provides
a
brief
overview
of
our
current
knowledge
about
septins
in
the
non-
neuronal
cells
of
the
vertebrate
nervous
system
,
collectively
termed
'
glial
cells
'
,
i
.
e
.
,
astrocytes
,
microglia
,
oligodendrocytes
,
and
Schwann
cells
.
The
dysregulation
of
septins
observed
in
various
models
of
myelin
pathology
is
discussed
with
respect
to
implications
for
hereditary
neuralgic
amyotrophy
(
HNA
)
caused
by
mutations
of
the
human
SEPT
9
-
gene
.
Diseases
Validation
Diseases presenting
"functional relevance"
symptom
canavan disease
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
inclusion body myositis
neuralgic amyotrophy
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