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Elimination of Aspergillus fumigatus conidia from the airways of mice with allergic airway inflammation.
[allergic bronchopulmonary aspergillosis]
Aspergillus
fumigatus
conidia
can
exacerbate
asthma
symptoms
.
Phagocytosis
of
conidia
is
a
principal
component
of
the
host
antifungal
defense
.
We
investigated
whether
allergic
airway
inflammation
(
AAI
)
affects
the
ability
of
phagocytic
cells
in
the
airways
to
internalize
the
resting
fungal
spores
.
Using
BALB
/
c
mice
with
experimentally
induced
AAI
,
we
tested
the
ability
of
neutrophils
,
macrophages
,
and
dendritic
cells
to
internalize
A
.
fumigatus
conidia
at
various
anatomical
locations
.
We
used
light
microscopy
and
differential
cell
and
conidium
counts
to
determine
the
ingestion
potential
of
neutrophils
and
macrophages
present
in
bronchoalveolar
lavage
(
BAL
)
.
To
identify
phagocyte-conidia
interactions
in
conducting
airways
,
conidia
labeled
with
tetramethylrhodamine-
(
5
-
(
and-
6
)
)
-
isothiocyanate
were
administered
to
the
oropharyngeal
cavity
of
mice
.
Confocal
microscopy
was
used
to
quantify
the
ingestion
potential
of
Ly-
6
G
+
neutrophils
and
MHC
II
+
antigen-presenting
cells
located
in
the
intraepithelial
and
subepithelial
areas
of
conducting
airways
.
Allergen
challenge
induced
transient
neutrophil
recruitment
to
the
airways
.
Application
of
A
.
fumigatus
conidia
at
the
acute
phase
of
AAI
provoked
recurrent
neutrophil
infiltration
,
and
consequently
increased
the
number
and
the
ingestion
potential
of
the
airway
neutrophils
.
In
the
absence
of
recurrent
allergen
or
conidia
provocation
,
both
the
ingestion
potential
and
the
number
of
BAL
neutrophils
decreased
.
As
a
result
,
conidia
were
primarily
internalized
by
alveolar
macrophages
in
both
AAI
and
control
mice
at
24
hours
post-inhalation
.
Transient
influx
of
neutrophils
to
conducting
airways
shortly
after
conidial
application
was
observed
in
mice
with
AAI
.
In
addition
,
the
ingestion
potential
of
conducting
airway
neutrophils
in
mice
with
induced
asthma
exceeded
that
of
control
mice
.
Although
the
number
of
neutrophils
subsequently
decreased
,
the
ingestion
capacity
remained
elevated
in
AAI
mice
,
even
at
24
hours
post-conidia
application
.
Aspiration
of
allergen
to
sensitized
mice
enhanced
the
ingestion
potential
of
conducting
airway
neutrophils
.
Such
activation
primes
neutrophils
so
that
they
are
sufficient
to
control
dissemination
of
non-germinating
A
.
fumigatus
conidia
.
At
the
same
time
,
it
can
be
a
reason
for
the
development
of
sensitivity
to
fungi
and
subsequent
asthma
exacerbation
.
Diseases
Validation
Diseases presenting
"absence of recurrent allergen"
symptom
allergic bronchopulmonary aspergillosis
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