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Biofilm formation by Aspergillus fumigatus.
[allergic bronchopulmonary aspergillosis]
Aspergillus
fumigatus
is
a
well
adapted
,
opportunistic
fungus
that
causes
a
severe
and
commonly
fatal
disease
,
invasive
pulmonary
aspergillosis
(
IPA
)
,
in
highly
immunocompromised
patients
,
aspergilloma
in
patients
with
lung
cavities
and
allergic
bronchopulmonary
aspergillosis
(
ABPA
)
in
hypersensitive
individuals
.
Recent
studies
have
suggested
that
biofilm
formation
by
A
.
fumigatus
may
be
one
of
the
most
important
virulence
factors
in
IPA
and
aspergilloma
.
Several
fungal
constituents
may
contribute
to
the
formation
of
biofilm
structures
on
host
cells
,
including
cell
wall
components
,
secondary
metabolites
and
drug
transporters
.
The
biofilm
phenotype
of
the
fungus
is
refractory
to
most
conventional
antifungal
treatment
options
.
Thus
,
an
in
-depth
analysis
and
understanding
of
A
.
fumigatus
biofilms
is
necessary
to
devise
newer
and
better
antifungal
targets
for
treating
complex
A
.
fumigatus
biofilm-associated
diseases
.
Diseases
Validation
Diseases presenting
"aspergilloma in patients with lung cavities and allergic bronchopulmonary aspergillosis"
symptom
allergic bronchopulmonary aspergillosis
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