Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis.

[allergic bronchopulmonary aspergillosis]

Cystic fibrosis is an autosomal recessive multisystem disorder with an approximate prevalence of 1 in 3500 live births . Allergic bronchopulmonary aspergillosis is a lung disease caused by aspergillus-induced hypersensitivity with a prevalence of 2 % to 15 % in people with cystic fibrosis . The mainstay of treatment includes corticosteroids and itraconazole . The treatment with corticosteroids for prolonged periods of time , or repeatedly for exacerbations of allergic bronchopulmonary aspergillosis , may lead to many adverse effects . The monoclonal anti-IgE antibody , omalizumab , has improved asthma control in severely allergic asthmatics . The drug is given as a subcutaneous injection every two to four weeks . Since allergic bronchopulmonary aspergillosis is also a condition resulting from hypersensitivity to specific allergens , as in asthma , it may be a candidate for therapy using anti-IgE antibodies . Therefore , anti-IgE therapy , using agents like omalizumab , may be a potential therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis .To evaluate the efficacy and adverse effects of anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis .We searched the Cochrane Cystic Fibrosis Trials Register , compiled from electronic database searches and handsearching of journals and conference abstract books . We also searched the reference lists of relevant articles and reviews . Last search : 21 January 2013 .We searched the ongoing trial registry clinicaltrials .gov for any ongoing trials . Latest search for clinicaltrials .gov : 22 February 2013 .Randomized and quasi-randomized controlled trials comparing anti-IgE therapy to placebo or other therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis .Two review authors independently extracted data and assessed the risk of bias in the included study . They planned to perform data analysis using Review Manager 5 .1 .Only one trial enrolling 14 patients was eligible for inclusion in the review . The study was terminated prematurely and complete data were not available . We contacted the study investigator and were told that the study was terminated due to the inability to recruit patients into the study despite all reasonable attempts . One or more serious side effects were encountered in six out of nine Â (66 .67 %) and one out of five Â (20 %) patients in omalizumab group and placebo group respectively .There is lack of evidence for the efficacy and safety of anti-IgE (omalizumab ) therapy in patients with cystic fibrosis and allergic bronchopulmonary aspergillosis . There is a need for large prospective randomized controlled trials of anti-IgE therapy in people with cystic fibrosis and allergic bronchopulmonary aspergillosis with both clinical and laboratory outcome measures such as steroid requirement , allergic bronchopulmonary aspergillosis exacerbations and lung function .

Diseases
Validation

Diseases presenting "lung disease" symptom

allergic bronchopulmonary aspergillosis

legionellosis

lymphangioleiomyomatosis

proteus syndrome

This symptom has already been validated