Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.
[monosomy 21]
The
squamous
cell
carcinoma
(
SCC
)
cell
lines
UM-SCC-
17
A
and
-
17
B
were
derived
,
respectively
,
from
the
primary
laryngeal
cancer
and
a
metastatic
neck
tumor
of
a
patient
who
failed
to
respond
to
radiation
therapy
but
achieved
long
-term
remission
after
surgery
.
The
karyotypes
of
both
cell
lines
and
a
subline
of
17
A
were
pseudodiploid
and
stable
in
multiple
in
vitro
passages
.
Several
karyotypic
abnormalities
were
common
to
all
three
cell
lines
and
therefore
represent
mutations
present
in
the
tumor
before
the
divergence
of
the
metastatic
and
subline
populations
whereas
those
rearrangements
observed
only
in
one
cell
are
more
likely
to
be
secondary
.
The
shared
mutations
include
:
duplication
of
the
short
and
proximal
long
arm
of
chromosome
2
,
isochromosome
3
q
,
duplication
7
,
inversion
8
,
duplication
of
the
distal
long
arm
of
18
,
and
monosomy
21
or
ring
21
.
Each
line
had
different
rearrangements
involving
chromosome
7
that
resulted
in
three
copies
of
most
of
the
short
arm
being
present
in
both
cell
lines
,
except
for
high
passages
of
17
B
,
in
which
one
structurally
normal
7
was
replaced
by
a
dicentric
isochromosome
,
dic
(
7
)
(
q
11
.
22
)
,
resulting
in
four
copies
of
7
p
.
The
dic
(
7
)
may
represent
an
in
vitro
mutation
.
An
isochromosome
13
q
was
noted
in
both
the
stemline
and
subline
of
UM-SCC-
17
A
but
not
in
UM-SCC-
17
B
.
A
del
(
11
p
)
and
an
iso
(
21
q
)
were
present
only
in
the
17
A
subline
.
The
cell
lines
expressed
the
membrane
antigen
phenotype
characteristic
of
squamous
cancers
although
the
UM-SCC-
17
A
subline
differed
with
respect
to
three
markers
.
Of
these
,
the
A
9
and
blood
group
antigen
changes
are
thought
to
be
associated
with
progression
.
The
subline
,
which
carried
the
del
(
11
)
(
p
13
-
p
15
.
1
)
,
also
failed
to
express
the
E
7
antigen
mapped
to
the
band
11
p
13
.
It
is
possible
that
the
two
apparently
normal
11
s
in
this
subline
carry
a
point
mutation
or
microscopically
undetected
deletion
involving
the
E
7
antigen
locus
.
Diseases
Validation
Diseases presenting
"progression"
symptom
esophageal squamous cell carcinoma
liposarcoma
monosomy 21
oral submucous fibrosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom