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Gene-dosage mapping of 30 DNA markers on chromosome 21.

[monosomy 21]

Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined.

Diseases presenting "the copy numbers of 30 chromosome 21 markers were assessed in the blood dna of 11 patients with partial trisomy or monosomy 21 and in the dna of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21" symptom

  • monosomy 21

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